Androgens modify Wnt agonists/antagonists expression balance in dermal papilla cells preventing hair follicle stem cell differentiation in androgenetic alopecia

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• 作者：Gustavo José ; Leiró ; s¹ ; Julieta Marí ; a Ceruti¹ ; Marí ; a Lí ; a Castellanos ; Ana Gabriela Kusinsky ; Marí ; a Eugenia Balañ ; á ; ; ^{mbalana@fundacioncassara.org.ar}
• 关键词：Androgenetic alopecia ; Epidermal stem cells ; Epithelial-mesenchymal interactions ; Dermal papilla ; Wnt ligands
• 刊名：Molecular and Cellular Endocrinology
• 出版年：2017
• 出版时间：5 January 2017
• 年：2017
• 卷：439
• 期：Complete
• 页码：26-34
• 全文大小：1300 K
• 卷排序：439

文摘

Androgens alter Wnt agonists/antagonists expression balance in dermal papilla. In dermal papilla cells (DPC) spheroids, Wnt agonists basal expression is favored. DKK-1 mimicked androgen inhibition on hair follicle stem cell (HFSC) differentiation. WNT10b overcame androgen inhibition of HFSC differentiation. Androgen action on DPC inhibits Wnt pathway in hair follicle differentiating cells.