Advanced glycation end products interfere with gastric smooth muscle contractile marker expression via the AGE/RAGE/NF-κB pathway

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• 作者：Ting Yu¹ ; Yongping Zheng¹ ; Yun Wang ; Wenjie Xiong ; Lin Lin ; ^{linlin9100@aliyun.com}
• 关键词：AGE ; advanced glycation end products ; SM ; smooth muscle ; RAGE ; advanced glycation end products receptor ; SMCs ; smooth muscle cells ; NF-κB ; nuclear factor-κB ; CML ; Nε-(carboxymethyl) lysine ; MHC ; myosin heavy chains ; GI ; gastrointestinal ; SD ; Sprague-Dawley ; STZ ; streptozotocin ; CCh ; carbachol ; HRP ; horseradish peroxidase ; PBS ; phosphate-buffered saline ; STZ-D ; STZ-induced diabetic ; DAB ; 3 ; 3-diaminobenzidin ; ROI ; region of interest ; SM-22α ; 22  ; kDa smooth muscle protein
• 刊名：Experimental and Molecular Pathology
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：102
• 期：1
• 页码：7-14
• 全文大小：1399 K
• 卷排序：102

文摘

We investigated AGEs involvement in diabetes-associated gastric dysmotility. STZ-induced diabetic rats had decreased SM MHC, α-actin, calponin gene expression. AGEs downregulated myocardin expression and activated NF-κB and RAGE. NF-κB inhibitor and anti-RAGE antibody blocked the effects of AGEs. Downregulated SM contractile protein and myocardin may induce gastric dysmotility.