Glucagon increases insulin levels by stimulating insulin secretion without effect on insulin clearance in mice

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• 作者：Gina Song^a ; Giovanni Pacini^b ; Bo Ahré ; n^c ; David Z. D&rsquo ; Argenio^a ; ^{dargenio@usc.edu}
• 关键词：Glucagon ; Insulin secretion ; Insulin clearance ; Population analysis
• 刊名：Peptides
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：88
• 期：Complete
• 页码：74-79
• 全文大小：751 K
• 卷排序：88

文摘

Glucagon effects on insulin kinetics in mice were assessed using population modeling analysis approach. Glucagon was shown to enhance prehepatic insulin secretion, but there was no effect on insulin clearance in mice. Our findings therefore show that the increase in circulating insulin achieved by glucagon is due to increased insulin secretion without any further influence on insulin clearance.