Different animal models of Central Diabetes Insipidus seem to be related to the specific neurobiological systems involved.

Some of their physiological and behavioral characteristics appear to depend on the availability of oxytocin (OT).

Thus, OT is present in Brattleboro rats but not in most animal models with acquired Central Diabetes Insipidus (CDI).

Both OT administration and decreased sodium intake appear to have a beneficial hydromineral effect on CDI.

Neuroendocrine correlates of human CDI suggest a greater resemblance to acquired CDI animal models than to Brattleboro rats.