Insulin on activation of autophagy with integrins and syndecans against MPP<sup>+</sup>-induced α-synuclein neurotoxicity

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Insulin on activation of autophagy with integrins and syndecans against MPP⁺-induced α-synuclein neurotoxicity

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作者：Mahesh Ramalingam ; Sung-Jin Kim ; Ph.D. ; ^{kimsj@khu.ac.kr" class="auth_mail" title="E-mail the corresponding author} (Prof.)
关键词：α-Syn ; SNCA ; α-synuclein ; Cox-2 ; cyclooxygenase-2 ; ILK ; integrin-linked kinase ; ITGAV ; integrin αV ; ITGB3 ; integrin β3 ; LDH ; lactate dehydrogenase ; MAP1LC3 ; microtubule-associated protein 1 light chain 3 ; MPP+ ; 1-Methyl-4-phenyl pyridinium ; SDC1 ; syndecan-1 ; SDC3 ; syndecan-3
刊名：Neuroscience Letters
出版年：2016
出版时间：28 October 2016
年：2016
卷：633
期：Complete
页码：94-100
全文大小：1775 K

文摘

•: Insulin inhibited MPP⁺-induced cell membrane damages.
•: Insulin also inhibited the Cox-2 and α-synuclein levels.
•: MPP⁺ and/or insulin enhanced the autophagy LC3.
•: Insulin enhanced the ILK and induced the integrins β3, αV, syndecan-1 and -3.
•: Insulin prevents MPP+-induced apoptosis in SH-SY5Y + RA cells.

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