A Sonic hedgehog coreceptor, BOC regulates neuronal differentiation and neurite outgrowth via interaction with ABL and JNK activation

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• 作者：Tuan Anh Vuong^a ; Young-Eun Leem^a ; Bok-Geon Kim^a ; Hana Cho^b ; Sang-Jin Lee^c ; Gyu-Un Bae^c ; Jong-Sun Kang^a ; ^{kangj01@skku.edu}
• 关键词：Shh ; Sonic hedgehog ; BOC ; Brother of CDO ; CDO ; cell adhesion molecular downregulated by ocogenes ; JNK ; Jun N-terminal kinase ; EC ; embryonal carcinoma cell ; NPC ; neural progenitor cell ; DCC ; deleted in colorectal cancer ; ROBO ; roundabout ; GLI ; glioma-associated oncogene ; JLP ; JNK-interacting protein 1-like protein ; MAPK ; mitogen activated protein kinase ; SH2 ; Src homology domain 2 ; SH3 ; Src homology domain 3 ; DCX ; doublecortin ; MAP2 ; microtubule-associating protein2 ; RA ; retinoic acid ; ITS ; insul
• 刊名：Cellular Signalling
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：30
• 期：Complete
• 页码：30-40
• 全文大小：2340 K
• 卷排序：30

文摘

Boc is required for neuronal differentiation and neurite outgrowth. ABL and JNK are implicated in neurogenesis. Boc interacts with SH2 domain of ABL via its YXXP motif. Boc-ABL interaction is critical for JNK activation. Boc promotes neurogenesis and neurite outgrowth through binding to ABL and JNK activation.