Differential response to intrahippocampal interleukin-4/interleukin-13 in aged and exercise mice

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• 作者：Alyssa Littlefield^a ; ^b ; ^{alyssa.littlefield@my.rfums.org} ; Rachel A. Kohman^a ; ^{kohmanr@uncw.edu}
• 关键词：Arg1 ; Arginase-1 ; BDNF ; brain derived neurotrophic factor ; Fizz1 ; found in inflammatory zone 1 ; IGF ; insulin-like growth factor ; IL ; interleukin ; IL-1ra ; IL-1 receptor antagonist ; LPS ; lipopolysaccharide ; PBS ; phosphate-buffered saline ; RT-PCR ; real-time polymerase chain reaction ; s.c. ; subcutaneous ; SEM ; standard error of the mean ; SOCS ; suppressor of cytokine signaling ; TBI ; traumatic brain injury ; TGF-β ; transforming growth factor-β ; TNF ; tumor necrosis factor ; Ym1 ; chitinase-like 3
• 刊名：Neuroscience
• 出版年：2017
• 出版时间：20 February 2017
• 年：2017
• 卷：343
• 期：Complete
• 页码：106-114
• 全文大小：601 K
• 卷排序：343

文摘

Aging dysregulates the anti-inflammatory response to IL-4 and IL-13. Exercise has minimal effects on the anti-inflammatory response in the aged. Aging increases hippocampal expression of interleukin-1 receptor antagonist.