Calcium channel blockers

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• 作者：Ian Whyte ; Nick Buckley ; Andrew Dawson
• 关键词：antidotes ; calcium channel blockers ; cardiotoxicity ; poisoning
• 刊名：Medicine
• 出版年：2012
• 出版时间：March, 2012
• 年：2012
• 卷：40
• 期：3
• 页码：112-114
• 全文大小：75 K

文摘

Overdose of calcium channel blockers is potentially lethal. Heart block with marked bradycardia and hypotension are the most important features. Verapamil and diltiazem are much more dangerous than dihydropyridines. Routine management usually comprises IV fluids, activated charcoal, whole bowel irrigation (for modified-release products) and prolonged ECG monitoring. Antidotes for cardiac effects include calcium, atropine, bicarbonate, high-dose insulin-euglycaemia, glucagon and vasopressors.