Lamin A is involved in the development of vascular calcification induced by chronic kidney failure and phosphorus load
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<p id="p0005">A high-phosphorus diet induced severe vascular calcification, decrease of renal function and higher mortality in uremic rats.p>
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<p id="p0010">Proteomics showed a distinct protein expression between non-calcified and calcified aortas, with lamin increase in the latter.p>
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<p id="p0015">VSMCs in calcifying media showed an increased binding of lamin with RUNX2, a major pro-osteoblastic transcription factor.p>
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<p id="p0020">Successful silencing of lamin prevented VSMCs' calcification and impaired the nuclear localization of RUNX2.p>
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<p id="p0025">Lamin A could play a key role in vascular calcification partly facilitating the nuclear localization of RUNX2.p>
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