Down-regulation of GJA3 is associated with lens epithelial cell apoptosis and age-related cataract

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• 作者：Dongmei Su^a ; ¹ ; Shanshan Hu^b ; ¹ ; Lina Guan^a ; Xinzhu Wu^a ; Cuige Shi^a ; ² ; ^{yushuiyushui@sina.com} ; Xiaobo Yang^b ; ² ; ^{17140893@qq.com} ; Xu Ma^a ; ² ; ^{jswkysgc@126.com} ; ^{genetic88@126.com}
• 关键词：GJA3 ; Lens epithelial cells apoptosis ; H2O2 ; Age-related cataract genesis
• 刊名：Biochemical and Biophysical Research Communications
• 出版年：2017
• 出版时间：26 February 2017
• 年：2017
• 卷：484
• 期：1
• 页码：159-164
• 全文大小：814 K
• 卷排序：484

文摘

Down-regulation of GJA3 was associated with H2O2 –induced apoptosis in LECs. GJA3 played a key role in mediating H2O2-induced apoptosis in LECs. GJA3 mutation partly inhibited the capacity of GJA3 to suppress apoptosis induced by H2O2 in lens epithelial cells. Down-regulation of GJA3 in the lens surface epithelial cells from lens tissue of the old mice.