Metformin protects the brain against ischemia/reperfusion injury through PI3K/Akt1/JNK3 signaling pathways in rats

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• 作者：Xu-Hua Ge^a ; Guo-Ji Zhu^b ; De-Qin Geng^c ; Han-Zhi Zhang^a ; Juan-Mei He^a ; Ai-Zhen Guo^a ; Lin-Lin Ma^a ; De-Hua Yu^a ; ^{tongjimge@163.com}
• 关键词：Ischemia/reperfusion ; Metformin ; Akt ; JNK3 ; Caspase-3
• 刊名：Physiology & Behavior
• 出版年：2017
• 出版时间：1 March 2017
• 年：2017
• 卷：170
• 期：Complete
• 页码：115-123
• 全文大小：1771 K
• 卷排序：170

文摘

Met attenuated neurological deficit induced by I/R. Met preserved striatum neurons survival after I/R. Met decreased JNK3 phosphorylation and cleaved caspase-3 expression through Akt1 signaling pathway after I/R.