Mechanistic insights into mitral regurgitation due to atrial fibrillation: “Atrial functional mitral regurgitation”

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• 作者：Jackson J. Liang ; DO ; Frank E. Silvestry ; MD ; FACC ; FASE ; ^{fsilvest@mail.med.upenn.edu" class="auth_mail" title="E-mail the corresponding author}
• 关键词：Atrial fibrillation ; Mitral regurgitation ; Functional mitral regurgitation ; Atrial functional mitral regurgitation ; Ablation ; Left atrium ; Mitral annulus
• 刊名：Trends in Cardiovascular Medicine
• 出版年：2016
• 出版时间：November 2016
• 年：2016
• 卷：26
• 期：8
• 页码：681-689
• 全文大小：1415 K

文摘

Mitral regurgitation (MR) is common, and definitive management of significant MR often requires percutaneous or surgical correction. Lone atrial fibrillation has been proposed to result in “atrial functional mitral regurgitation (AFMR)” via left atrial enlargement and mitral annular dilation. Patients with AFMR may represent a subgroup in which a rhythm control strategy may be preferred and catheter ablation is a promising nonsurgical therapy. This review discusses the anatomy of the mitral valve apparatus and MR classification schemes. Potential mechanisms in the pathogenesis of AFMR the implications for treatment will be discussed in detail.