Intravital FRAP Imaging using an E-cadherin-GFP Mouse Reveals Disease- and Drug-Dependent Dynamic Regulation of Cell-Cell Junctions in Live Tissue

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Intravital FRAP Imaging using an E-cadherin-GFP Mouse Reveals Disease- and Drug-Dependent Dynamic Regulation of Cell-Cell Junctions in Live Tissue

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作者：Zahra Erami¹ ; ⁵ ; David Herrmann² ; ⁵ ; Sean C. Warren² ; Max Nobis¹ ; Ewan J. McGhee¹ ; Morghan C. Lucas² ; Wilfred Leung² ; Nadine Reischmann² ; Agata Mrowinska¹ ; Juliane P. Schwarz¹ ; Shereen Kadir¹ ; James R.W. Conway² ; Claire Vennin² ; Saadia A. Karim¹ ; Andrew D. Campbell¹ ; David Gallego-Ortega² ; Astrid Magenau² ; Kendelle J. Murphy² ; Rachel A. Ridgway¹ ; Andrew M. Law² ; Stacey N. Walters² ; Shane T. Grey² ; David R. Croucher² ; Lei Zhang² ; Herbert Herzog² ; Edna C. Hardeman³ ; Peter W. Gunning⁴ ; Christopher J. Ormandy² ; T.R. Jeffry Evans¹ ; Douglas Strathdee¹ ; Owen J. Sansom¹ ; Jennifer P. Morton¹ ; Kurt I. Anderson¹ ; ⁶ ; ^{k.anderson@beatson.gla.ac.uk" class="auth_mail" title="E-mail the corresponding author} ; Paul Timpson² ; ⁶ ; ^{p.timpson@garvan.org.au" class="auth_mail" title="E-mail the corresponding author}
关键词：intravital imaging ; FRAP ; E-cadherin ; Src-kinase ; pancreatic cancer ; invasion and metastasis ; cell adhesion and migration ; Kras ; p53
刊名：Cell Reports
出版年：2016
出版时间：5 January 2016
年：2016
卷：14
期：1
页码：152-167
全文大小：13770 K

文摘

•: The E-cadherin-GFP mouse allows in situ quantification of E-cadherin mobility
•: We monitored E-cadherin mobility during tissue homeostasis and disease development
•: Invasive pancreatic cancer driven by mutant Kras/p53 increases E-cadherin mobility
•: Dasatinib treatment reverts E-cadherin mobility and reinforces tumor cell junctions

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