Immune responses elicited by the GEN-003 candidate HSV-2 therapeutic vaccine in a randomized controlled dose-ranging phase 1/2a trial

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Immune responses elicited by the GEN-003 candidate HSV-2 therapeutic vaccine in a randomized controlled dose-ranging phase 1/2a trial

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作者：Jessica Baker Flechtner ; ^{jessica.flechtner@genocea.com" class="auth_mail" title="E-mail the corresponding author} ; Deborah Long ; Shane Larson ; Veronica Clemens ; Amy Baccari ; Lena Kien ; Jason Chan ; Mojca Skoberne ; Matthew Brudner ; Seth Hetherington
关键词：Herpes simplex virus ; Vaccine ; Immunotherapy ; Immune response
刊名：Vaccine
出版年：2016
出版时间：17 October 2016
年：2016
卷：34
期：44
页码：5314-5320
全文大小：474 K

文摘

•: Cellular and humoral responses were boosted in GEN-003 vaccinated HSV-2 seropositive subjects.
•: Matrix-M2 adjuvant potentiated the immune responses to ICP4 and gD2 antigens contained in GEN-003.
•: No immune correlates of anti-viral activity have yet been identified.

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