A Genome-wide RNAi Screen for Microtubule Bundle Formation and Lysosome Motility Regulation in Drosophila S2 Cells

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A Genome-wide RNAi Screen for Microtubule Bundle Formation and Lysosome Motility Regulation in Drosophila S2 Cells

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作者：Amber L. Jolly¹ ; ³ ; Chi-Hao Luan² ; Brendon E. Dusel² ; Sara F. Dunne² ; Michael Winding¹ ; Vishrut J. Dixit¹ ; Chloe Robins² ; Jennifer L. Saluk² ; David J. Logan⁴ ; Anne E. Carpenter⁴ ; Manu Sharma³ ; Deborah Dean³ ; Andrew R. Cohen⁵ ; ^{acohen@coe.drexel.edu" class="auth_mail" title="E-mail the corresponding author} ; Vladimir I. Gelfand¹ ; ^{vgelfand@northwestern.edu" class="auth_mail" title="E-mail the corresponding author}
刊名：Cell Reports
出版年：2016
出版时间：26 January 2016
年：2016
卷：14
期：3
页码：611-620
全文大小：2602 K

文摘

•: 15,683 genes are targeted by RNAi and tested for lysosome motility
•: Lysosome motility is tracked in S2 cells along microtubule bundles
•: Dynein heavy and light chains are required for lysosome motility
•: Constitutively active Rab7a slows lysosome motility

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