Signaling via G proteins mediates tumorigenic effects of GPR87

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• 作者：Kristine Niss Arfelt¹ ; Suzan Fares¹ ; Alexander H. Sparre-Ulrich ; Gertrud M. Hjortø ; Læ ; rke S. Gasbjerg ; Ann-Sofie Mø ; lleskov-Jensen ; Tau Benned-Jensen² ; Mette M. Rosenkilde ; ^{Rosenkilde@sund.ku.dk}
• 关键词：7TM ; seven transmembrane ; AC ; adenylate cyclase ; BSA ; bovine serum albumin ; cAMP ; cyclic adenosine monophosphate ; CREB ; cAMP response element-binding protein ; CSC ; cancer stem cells ; CysLTs ; cysteinyl-leukotrienes ; ELISA ; Enzyme-linked immunosorbent assay ; ETAR ; endothelin A receptor ; FBS ; fetal bovine serum ; GPCRs ; G protein-coupled receptors ; HBS ; Hepes-buffered saline ; HCCs ; hepatocellular carcinomas ; hGPR87 ; human G protein-coupled receptor ; HHV ; human herpes virus ; HRP ; horseradish peroxida
• 刊名：Cellular Signalling
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：30
• 期：Complete
• 页码：9-18
• 全文大小：859 K
• 卷排序：30

文摘

Broad signaling of GPR87 via G proteins and downstream transcription factors. Strong cell transforming properties of GPR87 in a signaling-dependent manner. GPR87 induces cell clustering possibly via Rho/ROCK pathway. These properties position GPR87 as a potential future anti-cancer drug target.