Role of tripeptidyl peptidase II in MHC class I antigen presentation: Biological characteristics, cellular crosstalk and signaling

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• 作者：Quanhui Tan ; Siyuan Ma ; Jianjun Hu ; Xiaohua Chen ; Yongsheng Yu ; Guoqing Zang ; Zhenghao Tang ; ^{tzhhao@163.com}
• 关键词：TPPII ; MHC class I ; Antigen presentation
• 刊名：Biomedicine & Pharmacotherapy
• 出版年：2016
• 出版时间：December 2016
• 年：2016
• 卷：84
• 期：Complete
• 页码：1954-1958
• 全文大小：852 K
• 卷排序：84

文摘

Tripeptidyl peptidase II (TPPII) is a multifunctional cytoplasmic serine protease. The main function of TPPII is to cleave proteasome-generated peptides into tripeptides, which can then be further degraded into free amino acids. Recent evidence suggests that TPPII plays an important role in epitope generation, but the mechanisms of TPPII in MHC class I antigen presentation remain unclear. Recent research has shed new light on the mechanisms and functions of TPPII in MHC class I antigen presentation. We therefore provide an updated review of the biological characteristics of TPPII and explore its role in MHC class I antigen presentation.