Ds-HMGB1 and fr-HMGB induce depressive behavior through neuroinflammation in contrast to nonoxid-HMGB1

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• 作者：Yong-Jie Lian^a ; ¹ ; Hong Gong^a ; ¹ ; Teng-Yun Wu^b ; Wen-Jun Su^a ; Yi Zhang^a ; Yuan-Yuan Yang^a ; Wei Peng^a ; Ting Zhang^c ; Jiang-Rui Zhou^a ; Chun-Lei Jiang^a ; Yun-Xia Wang^a ; ^{cloudywang66@163.com}
• 关键词：HMGB1 protein ; Redox forms ; Depression ; TNF-α ; Myelin basic protein
• 刊名：Brain, Behavior, and Immunity
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：59
• 期：Complete
• 页码：322-332
• 全文大小：842 K
• 卷排序：59

文摘

Both ds-HMGB1 and fr-HMGB1 induce depressive behavior. The depressive behavior induced by ds-HMGB1 is related to TLR4 activation and a subsequent TNF-α increase. Fr-HMGB1 evokes depressive behavior through TLR4, RAGE and CXCR4, which are related to TNF-α induction. Nonoxid-HMGB1 cannot induce depressive behavior or a central TNF-α increase.