Beta-adrenergic receptor activation primes microglia cytokine production

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• 作者：John D. Johnson ; ^{jjohns72@kent.edu} ; Zachary R. Zimomra ; Luke T. Stewart
• 关键词：Norepinephrine ; IL-1 ; IL-6 ; Brain ; LPS ; Stress
• 刊名：Journal of Neuroimmunology
• 出版年：2013
• 出版时间：15 January, 2013
• 年：2013
• 卷：254
• 期：1-2
• 页码：161-164
• 全文大小：298 K

文摘

Exaggerated pro-inflammatory cytokine production by primed microglia is thought to mediate pathology during stress, aging, and neurodegeneration. Recently, it was demonstrated that beta-adrenergic receptor (¦Â-AR) antagonism prevents priming of microglia in mice exposed to chronic stress. To determine if ¦Â-AR stimulation is sufficient to prime microglia, rats were intra-cerebroventricularly administered isoproterenol (¦Â-AR agonist) or vehicle and 24 h later hippocampal microglia were placed in culture with media or LPS. Prior isoproterenol treatment significantly enhanced IL-1¦Â and IL-6, but not TNF-¦Á production following LPS stimulation. These data suggest that central ¦Â-AR stimulation is sufficient to prime microglia cytokine responses.