Context Specificity in Causal Signaling Networks Revealed by Phosphoprotein Profiling

详细信息    查看全文

• 作者：Steven M. Hill¹ ; ¹² ; Nicole K. Nesser² ; ¹² ; Katie Johnson-Camacho² ; Mara Jeffress³ ; Aimee Johnson⁴ ; Chris Boniface² ; Simon E.F. Spencer⁵ ; Yiling Lu⁶ ; Laura M. Heiser⁷ ; Yancey Lawrence² ; ¹³ ; Nupur T. Pande⁸ ; ⁹ ; James E. Korkola⁷ ; Joe W. Gray⁷ ; ⁹ ; ¹⁰ ; Gordon B. Mills⁶ ; Sach Mukherjee¹ ; ¹¹ ; ¹⁴ ; ^{sach.mukherjee@dzne.de} ; Paul T. Spellman² ; ¹⁵ ; ^{spellmap@ohsu.edu}
• 关键词：casual networks ; protein signaling networks ; context-specific networks ; breast cancer cell lines ; computational systems biology ; reverse-phase protein array data ; network inference ; empirical assessment ; data resource
• 刊名：Cell Systems
• 出版年：2017
• 出版时间：25 January 2017
• 年：2017
• 卷：4
• 期：1
• 页码：73-83.e10
• 全文大小：5170 K
• 卷排序：4

文摘

Time-course assays of signaling proteins in cancer cell lines under kinase inhibitionCausal conceptual framework for network analysisData shed light on causal protein networks that are specific to biological contextResource for signaling biology and for benchmarking computational methods