Targeting p38 or MK2 Enhances the Anti-Leukemic Activity of Smac-Mimetics

网站地图 | English | 公务邮箱

About the library

Background
History
Leadership
Organization

Opening Hours
Collections
Help Via Email

Electronic Information Resources

Targeting p38 or MK2 Enhances the Anti-Leukemic Activity of Smac-Mimetics

详细信息查看全文

作者：Najoua Lalaoui¹ ; ² ; Kay Hä ; nggi³ ; Gabriela Brumatti¹ ; ² ; Diep Chau¹ ; ² ; Nhu-Y.N. Nguyen⁴ ; ⁵ ; Lazaros Vasilikos³ ; Lisanne M. Spilgies³ ; Denise A. Heckmann¹ ; ² ; Chunyan Ma¹ ; ² ; Margherita Ghisi⁶ ; ⁷ ; Jessica M. Salmon⁶ ; ⁷ ; Geoffrey M. Matthews⁶ ; ⁷ ; Elisha de Valle⁸ ; ⁹ ; Donia M. Moujalled⁴ ; ⁵ ; Manoj B. Menon¹⁰ ; Sukhdeep Kaur Spall¹ ; ² ; Stefan P. Glaser¹ ; ² ; Jennifer Richmond¹¹ ; Richard B. Lock¹¹ ; Stephen M. Condon¹² ; Raffi Gugasyan⁸ ; ⁹ ; Matthias Gaestel¹⁰ ; Mark Guthridge⁴ ; ⁵ ; Ricky W. Johnstone⁶ ; ⁷ ; Lenka Munoz¹³ ; Andrew Wei⁴ ; ⁵ ; Paul G. Ekert¹ ; ¹⁴ ; ¹⁵ ; David L. Vaux¹ ; ² ; W. Wei-Lynn Wong³ ; John Silke¹ ; ² ; ^{silke@wehi.edu.au" class="auth_mail" title="E-mail the corresponding author}
刊名：Cancer Cell
出版年：2016
出版时间：8 February 2016
年：2016
卷：29
期：2
页码：145-158
全文大小：2667 K

文摘

•: Genetic loss or chemical inhibition of p38 or MK2 increases SM-induced TNF
•: p38 and MK2 inhibit SM-induced phosphorylation of JNK and ERK
•: The combination of SM and p38 inhibitor is well tolerated in vivo
•: p38 and MK2 inhibitors potentiate SM killing of AML in vivo

NGLC 2004-2010.National Geological Library of China All Rights Reserved.
Add:29 Xueyuan Rd,Haidian District,Beijing,PRC. Mail Add: 8324 mailbox 100083
For exchange or info please contact us via email.