Serum C-reactive protein in adolescence and risk of schizophrenia in adulthood: A prospective birth cohort study

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• 作者：Stephen A. Metcalf^a ; ¹ ; Peter B. Jones^a ; ¹ ; Tanja Nordstrom^b ; ^c ; Markku Timonen^b ; Pirjo M&auml ; ki^b ; ^c ; ^d ; ^e ; ^f ; ^g ; ^h ; ⁱ ; ^j ; Jouko Miettunen^b ; ^c ; Erika J&auml ; &auml ; skel&auml ; inen^b ; ^c ; Marjo-Riitta J&auml ; rvelin^b ; ^k ; ^l ; ^m ; Jan Stochl^a ; Graham K. Murray^a ; Juha Veijola^b ; ^c ; ² ; Golam M. Khandaker^a ; ² ; ^{gmk24@medschl.cam.ac.uk}
• 关键词：CRP ; C-reactive protein ; OR ; odds ratio ; IL ; interleukin ; TNFα ; tumour necrosis factor alpha ; ALSPAC ; Avon Longitudinal Study of Parents and Children ; NFBC ; Northern Finland Birth Cohort ; AHA ; American Heart Association ; CDC ; Centers for Disease Control and Prevention ; FHDR ; Finnish Hospital Discharge Register ; ICD-10 ; International Classification of Diseases ; 10th revision ; NAPLS ; North American Prodrome Longitudinal Study
• 刊名：Brain, Behavior, and Immunity
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：59
• 期：Complete
• 页码：253-259
• 全文大小：571 K
• 卷排序：59

文摘

This is one of the first longitudinal studies of serum CRP & subsequent schizophrenia. Elevated serum CRP in adolescence is associated with risk of adult schizophrenia. The CRP-schizophrenia association is consistent with a dose-response relationship.