Protective role of phenylalanine on the ROS-induced oxidative damage, apoptosis and tight junction damage via Nrf2, TOR and NF-κB signalling molecules in the gill of fish

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• 作者：Lin Feng^a ; ^b ; ^c ; ¹ ; Wen Li^a ; ¹ ; Yang Liu^a ; ^b ; ^c ; Wei-Dan Jiang^a ; ^b ; ^c ; Sheng-Yao Kuang^d ; Pei Wu^a ; ^b ; ^c ; Jun Jiang^a ; ^b ; ^c ; Ling Tang^d ; Wu-Neng Tang^d ; Yong-An Zhang^e ; Xiao-Qiu Zhou^a ; ^b ; ^c ; ^{xqzhouqq@tom.com} ; ^{zhouxq@sicau.edu.cn}
• 关键词：Phenylalanine ; Gill ; Tight junction ; Signalling molecule ; Immune
• 刊名：Fish & Shellfish Immunology
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：60
• 期：Complete
• 页码：185-196
• 全文大小：2247 K
• 卷排序：60

文摘

Phenylalanine deficiency impaired the structural integrity of fish gills. Phenylalanine deficiency decreased the gill antioxidant status of fish. Phenylalanine regulated the tight junction proteins mRNA levels of fish. Phenylalanine regulated Nrf2 and NF-κB signalling molecule mRNA levels in fish.