Pentasaccharide resin glycosides from Ipomoea cairica and their cytotoxic activities

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• 作者：Bangwei Yu ; Jianguang Luo ; Junsong Wang ; Dongming Zhang ; Shishan Yu ; Lingyi Kong
• 关键词：Ipomoea cairica ; Convolvulaceae ; Pentasaccharide ; Resin glycoside ; Cytotoxic activity
• 刊名：Phytochemistry
• 出版年：2013
• 出版时间：November, 2013
• 年：2013
• 卷：95
• 期：Complete
• 页码：421-427
• 全文大小：671 K

文摘

Six partially acylated pentasaccharide resin glycosides, cairicosides A-F, were isolated from the aerial parts of Ipomoea cairica. These compounds were characterized as a group of macrolactones of simonic acid A, partially acylated with different organic acids. The lactonization site of 11S-hydroxyhexadecanoic acid (jalapinolic acid) was bound to the second saccharide moiety at C-3 in cairicosides A-E, while at C-2 in cairicoside F. Structures were established by spectroscopic and chemical methods. Compounds cairicosides A-E exhibited moderate cytotoxicity against a small panel of human tumor cell lines with IC₅₀ values in the range of 4.28-14.31 ¦ÌM.