Labdane diterpenes from Chloranthus serratus

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• 作者：Mi Zhang ; Junsong Wang ; Jun Luo ; Pengran Wang ; Chao Guo ; Lingyi Kong
• 关键词：Labdane diterpene ; Chloranthus serratus ; Anti-inflammatory ; Induced circular dichroism
• 刊名：Fitoterapia
• 出版年：December, 2013
• 年：2013
• 卷：91
• 期：Complete
• 页码：95-99
• 全文大小：761 K

文摘

Five new labdane diterpenes (1-5), serralabdanes A-E, were isolated from the whole plant of Chloranthus serratus. Their structures were elucidated by spectroscopic methods, and the absolute configuration of the 12,13-diol moiety in serralabdane C (3) was determined by observing the induced circular dichroism (ICD) after addition of dimolybdenum teracetate in DMSO solution. Serralabdanes A-E (1-5) showed inhibitory effects on lipopolysaccharide-induced nitric oxide production in RAW264.7 cells.