Using an in vitro xenoantibody-mediated complement-dependent cytotoxicity model to evaluate the complement inhibitory activity of the peptidic C3 inhibitor Cp40

设为首页

收藏本站

网站地图 | English | 公务邮箱

About the library

Background
History
Leadership
Organization

Readers' Guide

Opening Hours
Collections
Help Via Email

Publications

Electronic Information Resources

Using an in vitro xenoantibody-mediated complement-dependent cytotoxicity model to evaluate the complement inhibitory activity of the peptidic C3 inhibitor Cp40

详细信息查看全文

作者：Junxiang Wang^a ; Lu Wang^a ; Ying Xiang^a ; ^b ; ^c ; Daniel Ricklin^d ; John D. Lambris^d ; Gang Chen^a ; ^b ; ^c ; ^{gchen@tjh.tjmu.edu.cn" class="auth_mail" title="E-mail the corresponding author} ; ^{gchentj@163.com" class="auth_mail" title="E-mail the corresponding author}
关键词：α-Gal ; Galα1-3Gal ; CDC ; complement-dependent cytotoxicity ; FACS ; fluorescence-activated cell sorter ; Gmean ; geometric mean fluorescence intensity ; HINHS ; heat-inactivated normal human serum ; HINMS ; heat-inactivated normal monkey serum ; iPEC ; SV40-immortalized porcine aortic endothelial cell line ; NHS ; normal human serum ; NHP ; nonhuman primate ; PI ; propidium iodide
刊名：Clinical Immunology
出版年：2016
出版时间：January 2016
年：2016
卷：162
期：Complete
页码：37-44
全文大小：1530 K

文摘

•: The in vitro xenoantibody-mediated CDC assay was shown to be reliable and translational to evaluate the complement inhibitory activity of peptidic C3 inhibitors.
•: More deposition of C4 fragments on iPECs was detected in the Cp40-pretreated group than that in Cp40-untreated group.
•: Effects of Cp40 on complement activation in humans and NHPs had an overall similar inhibitory pattern.