Social support and enhanced suppression of adrenocorticotropic hormone and cortisol responses to hypothalamic–pituitary–adrenal function and thyrotropin-releasing hormone tests in patien

详细信息    查看全文

• 作者：Jusen Tsuru ; Jotaro Akiyoshi ; Yoshihiro Tanaka ; Hirotaka Matsushita ; Hiroaki Hanada ; Kensuke Kodama ; Takatoshi Hikichi ; Hirochika Ohgami ; Takashi Tsutsumi ; Koichi Isogawa ; Haruo Nagayama
• 关键词：TRH test ; DEX/CRH test ; Depression ; Social support questionnaire ; Biological marker
• 刊名：Biological Psychology
• 出版年：2008
• 出版时间：May 2008
• 年：2008
• 卷：78
• 期：2
• 页码：159-163
• 全文大小：142 K

文摘

We investigated whether dexamethasone/corticotropin-releasing hormone (DEX/CRH) test parameters were related to the occurrence of relapse in 45 outpatients with clinically remitted major depression. The DEX/CRH test was administered before and after 8 weeks of antidepressant treatment.

Results

Posttreatment maximal adrenocorticotropic hormone (ACTH) and maximal cortisol levels, as well as delta ACTH and delta cortisol levels, were significantly higher (all p < .05) among patients who relapsed (n = 22) compared with patients in whom no relapse occurred (n = 23). Higher posttreatment maximal cortisol response on the DEX/CRH test was associated with shorter “relapse-free survival” (p = .05).

Conclusions

In outpatients with clinically remitted major depression, higher posttreatment maximal cortisol levels on the DEX/CRH test were associated with relapse of major depression.