Phase I/II Trial of Dose-Escalated Busulfan Delivered by Prolonged Continuous Infusion in Allogeneic Transplant Patients

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Phase I/II Trial of Dose-Escalated Busulfan Delivered by Prolonged Continuous Infusion in Allogeneic Transplant Patients

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作者：Thomas C. Shea¹ ; ² ; ^{sheat@med.unc.edu" class="auth_mail" title="E-mail the corresponding author} ; Christine Walko³ ; Yunro Chung⁴ ; Anastasia Ivanova² ; ⁴ ; Julia Sheets¹ ; Kamakshi Rao¹ ; Don Gabriel¹ ; ² ; Terry Comeau⁵ ; William Wood¹ ; ² ; James Coghill¹ ; ² ; Paul Armistead¹ ; ² ; Stefanie Sarantopoulos⁶ ; Jonathan Serody¹ ; ²
关键词：Busulfan ; Allogeneic ; Pharmacokinetics ; Dose escalation
刊名：Biology of Blood and Marrow Transplantation
出版年：2015
出版时间：December 2015
年：2015
卷：21
期：12
页码：2129-2135
全文大小：538 K

文摘

•: Determination of an AUC MTD with continuous-infusion busulfan in allogeneic transplantation.
•: Identification of rash and mucositis as the DLTs of high-dose continuous infusion busulfan.
•: Potential increased efficacy with an increased AUC of busulfan given as a continuous infusion.

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