Circadian Clock Interaction with HIF1α Mediates Oxygenic Metabolism and Anaerobic Glycolysis in Skeletal Muscle

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• 作者：Clara Bien Peek¹ ; Daniel C. Levine¹ ; Jonathan Cedernaes¹ ; Akihiko Taguchi¹ ; Yumiko Kobayashi¹ ; Stacy J. Tsai¹ ; Nicolle A. Bonar² ; Maureen R. McNulty³ ; Kathryn Moynihan Ramsey¹ ; Joseph Bass¹ ; ⁴ ; ^{j-bass@northwestern.edu}
• 关键词：circadian ; clock ; hypoxia ; skeletal muscle ; lactate ; HIF ; BMAL1 ; exercise ; glycolysis ; mitochondria
• 刊名：Cell Metabolism
• 出版年：2017
• 出版时间：10 January 2017
• 年：2017
• 卷：25
• 期：1
• 页码：86-92
• 全文大小：982 K
• 卷排序：25

文摘

Clock disruption in skeletal muscle reduces HIF1α activity and anaerobic glycolysis Genetic and hypoxic stabilization of HIF alters circadian transcription Maximal induction of HIF in response to exercise occurs in the early active period