Glucosamine induces autophagy via an mTOR-independent pathway

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• 作者：Tomoya Shintani ; Fumiyoshi Yamazaki ; Toshihiko Katoh ; Midori Umekawa ; Yoshiharu Matahira ; Seiji Hori ; Akira Kakizuka ; Kazuhide Totani ; Kenji Yamamoto ; Hisashi Ashida
• 关键词：Autophagy ; Chitin ; Chitosan ; Glucosamine ; Hexosamine ; Polyglutamine disease
• 刊名：Biochemical and Biophysical Research Communications
• 出版年：2010
• 出版时间：22 January 2010
• 年：2010
• 卷：391
• 期：4
• 页码：1775-1779
• 全文大小：1257 K

文摘

Autophagy is a cellular process that nonspecifically degrades cytosolic components and is involved in many cellular responses. We found that amino sugars with a free amino group such as glucosamine, galactosamine and mannosamine induced autophagy via an mTOR-independent pathway. Glucosamine-induced autophagy at concentrations of at least 500 μM to over 40 mM. In the presence of 40 mM glucosamine, autophagy induction was initiated at 6 h and reached a plateau at 36 h. Glucosamine-induced autophagy could remove accumulated ubiquitin-conjugated proteins as well as 79-glutamine repeats. Therefore, orally administered glucosamine could contribute to the prevention of neurodegenerative diseases and promotion of antiaging effects.