Reductive aminopropylation of ketene silyl (thio)acetals leading to the synthesis of ¦Ä-amino esters

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• 作者：Isao  ; Mizota ; Shun  ; Agatani ; Iwao  ; Hachiya ; Makoto  ; Shimizu  ; ;   ; ^{mshimizu@chem.mie-u.ac.jp}
• 关键词：Aminopropylation ; Ketene silyl acetal ; Ketene silyl thioacetal ; ¦Á ; ¦Â-Unsaturated aldimine ; ¦Ä-Amino esters
• 刊名：Tetrahedron Letters
• 出版年：2011
• 出版时间：12 October 2011
• 年：2011
• 卷：52
• 期：41
• 页码：5388-5391
• 全文大小：551 K

文摘

In the presence of silica gel or titanium tetrachloride, ketene silyl acetals or ketene silyl thioacetals underwent 1,4-addition with ¦Á,¦Â unsaturated aldimines which possess a large triphenylmethyl group at the imino nitrogens followed by reduction with sodium cyanoborohydride to give aminopropylated products, ¦Ä-amino esters, in good yields.