The APC/C Coordinates Retinal Differentiation with G1 Arrest through the Nek2-Dependent Modulation of Wingless Signaling

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• 作者：Torcato Martins<sup>1sup><sup> ; sup><sup>tjn29@cam.ac.uksup> ; Francesco Meghini<sup>1sup> ; Francesca Florio<sup>1sup> ; Yuu Kimata<sup>1sup><sup> ; sup><sup>2sup><sup> ; sup><sup>yk299@cam.ac.uksup>
• 关键词：APC/C ; proteolysis ; wingless ; Wnt ; Drosophila ; Nek2 ; eye development ; Dpp ; differentiation ; fate specification
• 刊名：Developmental Cell
• 出版年：2017
• 出版时间：9 January 2017
• 年：2017
• 卷：40
• 期：1
• 页码：67-80
• 全文大小：8036 K
• 卷排序：40

文摘

APC/C inactivation disrupts retinal differentiation in the Drosophila eye APC/C inactivation causes the ectopic activation of Wg signaling APC/CFzr downregulates a Wg modulator, dNek2, by proteolysis upon G1 arrest Local dNek2 degradation ensures the coordination of retinal differentiation