The miR-17∼92 cluster contributes to MLL leukemia through the repression of MEIS1 competitor PKNOX1

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The miR-17∼92 cluster contributes to MLL leukemia through the repression of MEIS1 competitor PKNOX1

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作者：Yousaf A. Mian^a ; Nancy J. Zeleznik-Le^a ; ^b ; ^{nzelezn@luc.edu" class="auth_mail" title="E-mail the corresponding author}
关键词：MLL ; miRNA ; miR-17&sim ; 92 ; PKNOX1 ; MEIS1 ; Leukemia
刊名：Leukemia Research
出版年：2016
出版时间：July 2016
年：2016
卷：46
期：Complete
页码：51-60
全文大小：3088 K

文摘

ass="label">•: ar0005">Treatment with anti-miRNA oligos decreases MLL leukemia cell line colony formation.
ass="label">•: ar0010">The miR-17 and miR-19 miRNA families target the MEINOX family member PKNOX1.
ass="label">•: ar0015">PKNOX1 and MEIS1 compete for inclusion into PBX-containing complexes.
ass="label">•: ar0020">Enforced Pknox1 expression reduces MLL-AF9 leukemia colony formation ability.

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