Pretreatment with a γ-Secretase Inhibitor Prevents Tumor-like Overgrowth in Human iPSC-Derived Transplants for Spinal Cord Injury

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Pretreatment with a γ-Secretase Inhibitor Prevents Tumor-like Overgrowth in Human iPSC-Derived Transplants for Spinal Cord Injury

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作者：Toshiki Okubo¹ ; ² ; Akio Iwanami¹ ; Jun Kohyama² ; Go Itakura² ; Soya Kawabata¹ ; Yuichiro Nishiyama¹ ; Keiko Sugai¹ ; Masahiro Ozaki¹ ; ² ; Tsuyoshi Iida¹ ; ² ; Kohei Matsubayashi¹ ; ² ; Morio Matsumoto¹ ; Masaya Nakamura¹ ; ^{masa@a8.keio.jp" class="auth_mail" title="E-mail the corresponding author} ; Hideyuki Okano² ; ^{hidokano@a2.keio.jp" class="auth_mail" title="E-mail the corresponding author}
刊名：Stem Cell Reports
出版年：2016
出版时间：11 October 2016
年：2016
卷：7
期：4
页码：649-663
全文大小：4019 K

文摘

•: GSI-treated hiPSC-NS/PCs induced neuronal differentiation and maturation
•: GSI-treated hiPSC-NS/PCs integrated into the reconstructed host neuronal network
•: Grafted GSI-treated hiPSC-NS/PCs prevented tumor-like overgrowth following SCI
•: Grafted GSI-treated hiPSC-NS/PCs maintained functional recovery following SCI

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