Olfactory Plays a Key Role in Spatiotemporal Pathogenesis of Cerebral Malaria

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Olfactory Plays a Key Role in Spatiotemporal Pathogenesis of Cerebral Malaria

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作者：Hong Zhao¹ ; ¹⁴ ; Taiki Aoshi² ; ⁷ ; ¹⁴ ; Satoru Kawai⁸ ; ¹⁴ ; Yuki Mori⁶ ; Aki Konishi¹ ; Muge Ozkan¹ ; Yukiko Fujita¹ ; Yasunari Haseda⁷ ; Mikiko Shimizu¹ ; Masako Kohyama³ ; Kouji Kobiyama² ; ⁷ ; Kei Eto⁹ ; Junichi Nabekura⁹ ; Toshihiro Horii¹⁰ ; Tomoko Ishino¹¹ ; Masao Yuda¹¹ ; Hiroaki Hemmi⁴ ; Tsuneyasu Kaisho⁴ ; Shizuo Akira⁵ ; Manabu Kinoshita¹² ; Koujiro Tohyama¹³ ; Yoshichika Yoshioka⁶ ; ¹⁵ ; Ken J. Ishii² ; ⁷ ; ¹⁵ ; Cevayir Coban¹ ; ¹⁵ ; ^{ccoban@biken.osaka-u.ac.jp" class="auth_mail}
刊名：Cell Host Microbe
出版年：14 May 2014
年：2014
卷：15
期：5
页码：551-563
全文大小：4254 K

文摘

•: Ultra-high-field MRI imaging identifies a vulnerable spot in brain during ECM
•: Intravital imaging shows Plasmodium parasites adhere in the olfactory bulb
•: High fever and olfaction loss associate with brain dysfunction during ECM
•: OLF astrocytes and CCL21 may regulate CD11c+ CD8 T cell entry via CXCR3

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