Preparation of 2,2-disubstituted 1,2-dihydro-3H-indol-3-ones via oxidation of 2-substituted indoles and Mannich-type reaction

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Preparation of 2,2-disubstituted 1,2-dihydro-3H-indol-3-ones via oxidation of 2-substituted indoles and Mannich-type reaction

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作者：Kazuhiro Higuchi ; Yukihiro Sato ; Shigeru Kojima ; Mei Tsuchimochi ; Kenta Sugiura ; Masatoshi Hatori ; Tomomi Kawasaki
关键词：Oxidation of indole ; Mannich-type reaction ; 2 ; 2-Disubstituted 1 ; 2-dihydro-3H-indol-3-one ; C-Acyliminium intermediate
刊名：Tetrahedron
出版年：2010
出版时间：6 February 2010
年：2010
卷：66
期：6
页码：1236-1243
全文大小：360 K

文摘

A novel preparative method for 2,2-disubstituted 1,2-dihydro-3H-indol-3-ones through the oxidation of 2-arylindoles followed by a Mannich-type reaction with carbon nucleophiles is described.