A flavanone derivative from the Asian medicinal herb (Perilla frutescens) potently suppresses IgE-mediated immediate hypersensitivity reactions

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• 作者：Rikiya Kamei^a ; Takashi Fujimura^a ; Miki Matsuda^a ; Kotaro Kakihara^a ; Noriko Hirakawa^b ; Kenji Baba^b ; Kazuhisa Ono^a ; ^c ; Kenji Arakawa^a ; Seiji Kawamoto^a ; ^{skawa@hiroshima-u.ac.jp}
• 关键词：Allergy ; IgE ; Mast cells ; Perilla frutescens ; Polyphenols
• 刊名：Biochemical and Biophysical Research Communications
• 出版年：2017
• 出版时间：29 January 2017
• 年：2017
• 卷：483
• 期：1
• 页码：674-679
• 全文大小：604 K
• 卷排序：483

文摘

A new potent mast cell degranulation inhibitory flavanone (PDMF) was discovered. PDMF significantly prevented PCA as well as allergic pollinosis-like nasal symptoms. PDMF suppressed Akt phosphorylation and intracellular calcium influx upon FcεRI ligation.