Mitochondrial reactive oxygen species mediate the lipopolysaccharide-induced pro-inflammatory response in human gingival fibroblasts

网站地图 | English | 公务邮箱

About the library

Background
History
Leadership
Organization

Opening Hours
Collections
Help Via Email

Electronic Information Resources

Mitochondrial reactive oxygen species mediate the lipopolysaccharide-induced pro-inflammatory response in human gingival fibroblasts

详细信息查看全文

作者：Xue Li^a ; Xiaoxuan Wang^a ; Ming Zheng^b ; ^{zhengm@bjmu.edu.cn" class="auth_mail" title="E-mail the corresponding author} ; Qing Xian Luan^a ; ^{kqluanqx@126.com" class="auth_mail" title="E-mail the corresponding author}
关键词：DMEM ; Dulbecco's Modified Eagle's Medium ; ELISA ; enzyme-linked immunosorbent assay ; EMSA ; electrophoretic mobility-shift assay ; H2DCFDA ; 5 ; 6-chloromethyl-2&prime ; 7&prime ; - dichlorodihydrofluorescein diacetate ; acetyl ester ; HGF ; human gingival fibroblast ; IKK ; inhibitor of nuclear factor-κB kinase ; IL ; interleukin ; JNK ; c-Jun N-terminal kinase ; LPS ; lipopolysaccharides ; MAPK ; mitogen-activated protein kinase ; MnSOD ; manganese superoxide dismutase ; mtROS ; mitochondrial reactive oxygen species ; N
刊名：Experimental Cell Research
出版年：2016
出版时间：10 September 2016
年：2016
卷：347
期：1
页码：212-221
全文大小：3854 K

文摘

•: Inflammation is thought to promote pathogenic changes in periodontitis.
•: We investigated mtROS as a regulator of inflammation in gingival fibroblasts.
•: Targeted antioxidants were used to inhibit mtROS production after LPS challenge.
•: Inhibiting mtROS generation suppressed the secretion of pro-inflammatory cytokines.
•: JNK, p38, IKK, and NF-κB were shown to act as transducers of mtROS signaling.

NGLC 2004-2010.National Geological Library of China All Rights Reserved.
Add:29 Xueyuan Rd,Haidian District,Beijing,PRC. Mail Add: 8324 mailbox 100083
For exchange or info please contact us via email.