The evaluation of endothelin 1 (EDN1) and endothelin receptor type A (EDNRA) gene polymorphisms in Hashimoto's thyroiditis

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The evaluation of endothelin 1 (EDN1) and endothelin receptor type A (EDNRA) gene polymorphisms in Hashimoto's thyroiditis

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作者：A. Fatih Aydin^a ; Pervin Vural^a ; ^{pervinvural@yahoo.com" class="auth_mail} ; Ç ; o艧kun Umut Oruç ; ^a ; Semra Do臒ru-Abbaso臒lu^a ; Ay艧enur &Ouml ; zderya^b ; Berrin Karada臒^b ; Mü ; jdat Uysal^a
关键词：Anti-Tg ; anti-thyroglobulin ; Anti-TPO ; anti-thyroid peroxidase ; CI ; confidence interval ; GD ; Graves' disease ; EDN1 ; endothelin 1 ; EDNRA ; endothelin receptor type A ; HT ; Hashimoto's thyroiditis ; HWE ; Hardy&ndash ; Weinberg equilibrium ; ICAM1 ; intercellular adhesion molecule 1 ; LD ; linkage disequilibrium ; NF-魏B ; nuclear factor-魏B ; OR ; odds ratio ; SNPs ; single nucleotide polymorphisms ; TSH ; thyroid-stimulating hormone ; VEGF ; vascular endothelial growth factor ; UTR ; untranslated region
刊名：International Immunopharmacology
出版年：July 2014
年：2014
卷：21
期：1
页码：181-185
全文大小：280 K

文摘

•: This study investigates the relationships between EDN1 family genes and HT.
•: EDN1 (G5665T, T-1370G) and EDNRA (C+70G, G-231A) SNPs were assayed by real-time PCR.
•: No significant associations between HT and variant alleles or haplotypes were found.
•: Strong (EDNRA − 231/+ 70) and weak (EDN1 − 1370/5665) linkage disequilibrium were found.
•: The EDNRA + 70 G allele had protective effect against early disease onset of HT.

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