Lack of association between LRRK2 G2385R and cognitive dysfunction in Korean patients with Parkinson’s disease

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• 作者：Jeong Hoon Hong^a ; Yue Kyung Kim^b ; Jae Seol Park^b ; Ji Eun Lee^c ; Mi Sun Oh^b ; Eun Joo Chung^d ; Jeong-Yeon Kim^e ; Young-Hee Sung^f ; Chul Hyoung Lyoo^g ; Jae Hyeok Lee^h ; Do-Young Kwonⁱ ; Hyun Sook Kim^j ; Hae-Won Shin^k ; Sun Ah Park^l ; In-Seok Park^m ; Joong-Seok Kim^m ; Phil Hyu Leeⁿ ; Seong-Beom Koh^o ; Jong Sam Baik^e ; Sang Jin Kim^d ; Hyeo-Il Ma^b ; Jae Woo Kim^p ; Yun Joong Kim^a ; ^b ; ^q ; ^{yunkim@hallym.ac.kr}
• 关键词：Cognitive impairment ; Idiopathic Parkinson&rsquo ; s disease ; Leucine-rich repeat kinase 2 ; Genetic risk factor ; Polymorphism
• 刊名：Journal of Clinical Neuroscience
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：36
• 期：Complete
• 页码：108-113
• 全文大小：736 K
• 卷排序：36

文摘

Longer PD duration, older age-at-study entry and presence of depression were associated with cognitive dysfunction in PD. Heterozygous carrier of G2385R of LRRK2 was found in 7.7% of Parkinson’s disease (PD) patients. There was no association between LRRK2 G2385R genotype and cognitive dysfunction assessed by MMSE Z score or MoCA in PD. The interaction terms between PD duration and the LRRK2 G2385R genotype were not significant for the MMSE Z score. There was an interaction between PD duration and LRRK2 G2385R genotype for cognitive decline assessed by MoCA score in PD.