Not All H3K4 Methylations Are Created Equal: Mll2/COMPASS Dependency in Primordial Germ Cell Specification

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• 作者：Deqing Hu¹ ; ² ; Xin Gao² ; Kaixiang Cao¹ ; Marc A. Morgan¹ ; Gloria Mas³ ; ⁴ ; Edwin R. Smith¹ ; Andrew G. Volk¹ ; ⁵ ; Elizabeth T. Bartom¹ ; John D. Crispino¹ ; ⁵ ; ⁷ ; Luciano Di Croce³ ; ⁴ ; ⁶ ; Ali Shilatifard¹ ; ² ; ⁷ ; ⁸ ; ^{ash@northwestern.edu}
• 关键词：Histone-Lysine N-Methyltransferase ; chromatin ; histone ; mouse embryonic stem cell ; embryonic development ; primordial germ cell ; gene expression regulation ; Mll2 ; Kmt2b ; CXXC domain
• 刊名：Molecular Cell
• 出版年：2017
• 出版时间：2 February 2017
• 年：2017
• 卷：65
• 期：3
• 页码：460-475.e6
• 全文大小：8574 K
• 卷排序：65

文摘

Mll2/COMPASS occupies and catalyzes H3K4me3 at non-TSS elements The CXXC domain of Mll2/COMPASS mediates its chromatin targeting Mll2 regulates transcription of some genes including PGC specification genes PGC specification requires Mll2/COMPASS’s methyltransferase activity