The prevalence of early subclinical somatic neuropathy in children and adolescents with Type 1 diabetes mellitus and its association with the persistence of autoantibodies to glutamic acid decarboxylase (GAD) and islet antigen-2 (IA-2)

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The prevalence of early subclinical somatic neuropathy in children and adolescents with Type 1 diabetes mellitus and its association with the persistence of autoantibodies to glutamic acid decarboxylase (GAD) and islet antigen-2 (IA-2)

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作者：Maria Louraki^a ; Marina Katsalouli^b ; Christina Kanaka-Gantenbein^c ; Nikolitsa Kafassi^d ; Eleni Critselis^a ; Dimitra Kallinikou^a ; Charalampos Tsentidis^a ; Kyriaki Karavanaki^a ; ^{kkarav@yahoo.gr" class="auth_mail" title="E-mail the corresponding author} ; ^{mlouraki@hotmail.com" class="auth_mail" title="E-mail the corresponding author}
关键词：DN ; diabetic neuropathy ; Type 1 DM ; Type 1 diabetes ; GADA ; glutamic acid decarboxylase autoantibodies ; IA-2A ; islet antigen-2 autoantibodies ; NCS ; nerve conduction studies ; BMI ; body mass index ; SDS ; standard deviation score ; SNAP ; sensory nerve action potential ; CMAP ; compound muscle action potential ; SCV ; sensory conduction velocity ; MCV ; motor conduction velocity ; DML ; distal motor latency ; SL ; sensory latency
刊名：Diabetes Research and Clinical Practice
出版年：2016
出版时间：July 2016
年：2016
卷：117
期：Complete
页码：82-90
全文大小：333 K

文摘

•: Among examined nerves, the sensory peroneal nerve had the highest abnormality rates.
•: The persistence of GADA and IA-2A was associated to slower peronial action potentials.
•: Autoantibodies may be involved in axonal degeneration in early diabetic neuropathy.