Increased anxiety but normal fear and safety learning in orexin-deficient mice

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• 作者：Radwa Khalil^a ; ¹ ; Markus Fendt^a ; ^b ; ^{markus.fendt@med.ovgu.de}
• 关键词：Hypocretin ; Light-dark box ; Locomotor activity ; Open field ; Predator odor avoidance ; Unconditioned fear
• 刊名：Behavioural Brain Research
• 出版年：2017
• 出版时间：1 March 2017
• 年：2017
• 卷：320
• 期：Complete
• 页码：210-218
• 全文大小：1382 K
• 卷排序：320

文摘

Orexin knockout mice were used to investigated orexin’s role in fear and anxiety. Orexin deficiency did not change locomotor behavior. Orexin deficiency did not affect fear and safety learning. Orexin deficiency did not affect the locomotor response to foot shocks. Orexin deficiency increased anxiety in open field, light-dark box and predator avoidance.