Prevention of Dietary-Fat-Fueled Ketogenesis Attenuates BRAF V600E Tumor Growth

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• 作者：Siyuan Xia¹ ; Ruiting Lin¹ ; Lingtao Jin¹ ; Liang Zhao¹ ; Hee-Bum Kang¹ ; Yaozhu Pan¹ ; Shuangping Liu¹ ; Guoqing Qian¹ ; Zhiyu Qian¹ ; Evmorfia Konstantakou¹ ; Baotong Zhang¹ ; Jin-Tang Dong¹ ; Young Rock Chung³ ; Omar Abdel-Wahab³ ; Taha Merghoub³ ; Lu Zhou⁴ ; Ragini R. Kudchadkar¹ ; David H. Lawson¹ ; Hanna J. Khoury¹ ; Fadlo R. Khuri¹ ; Lawrence H. Boise¹ ; Sagar Lonial¹ ; Benjamin H. Lee⁵ ; Brian P. Pollack⁶ ; ⁷ ; Jack L. Arbiser⁶ ; ⁷ ; Jun Fan² ; ^{jfan3@emory.edu} ; Qun-Ying Lei⁴ ; ^{qlei@fudan.edu.cn} ; Jing Chen¹ ; ⁸ ; ^{jchen@emory.edu}
• 关键词：BRAF V600E ; ketogenesis ; acetoacetate ; precision diet ; cancer therapy ; cancer metabolism ; cancer risk ; dietary fat ; cancer prevention ; dehydroacetic acid
• 刊名：Cell Metabolism
• 出版年：2017
• 出版时间：7 February 2017
• 年：2017
• 卷：25
• 期：2
• 页码：358-373
• 全文大小：6307 K
• 卷排序：25

文摘

Dietary fat promotes ketogenesis to enhance BRAF V600E tumor growth Hypolipidemic agents inhibit BRAF V600E tumor growth Dehydroacetic acid competes with acetoacetate for BRAF V600E binding “Precision diet” can lower cancer risk and provide cancer prevention