Peripheral administration of interleukin-13 reverses inflammatory macrophage and tactile allodynia in mice with partial sciatic nerve ligation

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• 作者：Norikazu Kiguchi ; ^{kiguchi@wakayama-med.ac.jp} ; Haruka Sakaguchi ; Yui Kadowaki ; Fumihiro Saika ; Yohji Fukazawa ; Shinsuke Matsuzaki ; Shiroh Kishioka
• 关键词：Cytokine ; Chemokine ; Neuroinflammation
• 刊名：Journal of Pharmacological Sciences
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：133
• 期：1
• 页码：53-56
• 全文大小：735 K
• 卷排序：133

文摘

Inflammatory macrophages play a fundamental role in neuropathic pain. In this study, we demonstrate the effects of peripheral interleukin-13 (IL-13) on neuropathic pain after partial sciatic nerve (SCN) ligation (PSL) in mice. IL-13 receptor α1 was upregulated in accumulating macrophages in the injured SCN after PSL. Treatment with IL-13 reduced inflammatory macrophage-dominant molecules and increased suppressive macrophage-dominant molecules in cultured lipopolysaccharide-stimulated peritoneal macrophages and ex vivo SCN subjected to PSL. Moreover, the perineural administration of IL-13 relieved tactile allodynia after PSL. These results suggest that IL-13 reverses inflammatory macrophage-dependent neuropathic pain via a phenotype shift toward suppressive macrophages.