The heparin-like activities of negatively charged derivatives of low-molecular-weight polymannuronate and polyguluronate
文摘

LPM and LPG were prepared from alginate and studied side-by-side.

LPM and LPG derivatives containing −PO32−, −PO2H and −SO3 were synthesized.

SO3 modification of LPM and LPG enhanced the anticoagulant and FGFs/FGFR1c signaling activation activities.

Sulfated LPG had better heparin-like activities than sulfated LPM.

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