The Abscission Checkpoint: Making It to the Final Cut

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• 作者：Viola Nä ; hse¹ ; ² ; Liliane Christ¹ ; ² ; Harald Stenmark¹ ; ² ; ³ ; ^{stenmark@ulrik.uio.no} ; Coen Campsteijn¹ ; ² ; ^{coen.campsteijn@rr-research.no}
• 关键词：cytokinesis ; genome instability ; chromatin bridge ; membrane scission ; Aurora B ; ESCRT-III ; NoCut
• 刊名：Trends in Cell Biology
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：27
• 期：1
• 页码：1-11
• 全文大小：1660 K
• 卷排序：27

文摘

Cytokinesis is the final stage of cell division and is concluded by abscission of the intercellular bridge to physically separate the daughter cells. Timing of cytokinetic abscission is monitored by a molecular machinery termed the abscission checkpoint. This machinery delays abscission in cells with persistent chromatin in the intercellular bridge. Recent work has also uncovered its response to high membrane tension, nuclear pore defects, and DNA replication stress. Although it is known that the abscission checkpoint depends on persistent activity of the Aurora B protein kinase, we have only recently begun to understand its molecular basis. We propose here a molecular framework for abscission checkpoint signaling and we discuss outstanding questions relating to its function and physiological relevance.