Synthesis and antiviral evaluation of novel N-6 substituted adenosine analogues

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• 作者：Youwu Hao^a ; Gaohui Zhou^a ; Wei Wu^a ; Yang Zhang^a ; Liming Tao^a ; Jianhua Yao^b ; Wenping Xu^a ; ^{xuwp@ecust.edu.cn}
• 关键词：Adenosine analogues ; Antiviral activities ; Coxsackie virus B3 ; Herpes simplex virus type 1 ; Higher selectivity index
• 刊名：Tetrahedron Letters
• 出版年：2017
• 出版时间：18 January 2017
• 年：2017
• 卷：58
• 期：3
• 页码：190-193
• 全文大小：394 K
• 卷排序：58

文摘

A novel series of adenosine analogues were synthesized as antiviral agents. The phenyl substitution of piperazine moiety may more effective. Compounds 8b exhibited better inhibitory activities against CVB3 than Ribavirin. The target compounds were designed by computer simulation. These kinds of adenosine analogues might be developed as potent antiviral agents.