Fabrication and characterization of porous β-tricalcium phosphate scaffolds coated with alginate

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• 作者：Nur Amyra Shazni Zairani ; Mariatti Jaafar ; ^{mariatti@usm.my" class="auth_mail" title="E-mail the corresponding author} ; Nurazreena Ahmad ; Khairunisak Abdul Razak
• 关键词：Porous β-TCP scaffolds ; Liquid-nitrogen freeze-casting method ; Combination of direct-foaming and sacrificial-template methods
• 刊名：Ceramics International
• 出版年：2016
• 出版时间：March 2016
• 年：2016
• 卷：42
• 期：4
• 页码：5141-5147
• 全文大小：1475 K

文摘

All porous materials have a common limitation which is lack of strength due to the porosity. In this study, two different methods have been used to produce porous β-tricalcium phosphate (β-TCP) scaffolds: liquid-nitrogen freeze casting and a combination of the direct-foaming and sacrificial-template methods. Among these two methods, porous β-TCP scaffolds with acceptable pore size and compressive strength and defined pore-channel interconnectivity were successfully fabricated by the combined direct-foaming and sacrificial-template method. The average pore size of the scaffolds was in the range of 100–150 µm and the porosity was around 70%. Coating with 4 wt% alginate on porous β-TCP scaffolds led to higher compressive strength and low porosity. In order to make a chemical link between the β-TCP scaffolds and the alginate coating, silane coupling agent was used. Treated β-TCP scaffold showed improvements in compressive strength of up to 38% compared to the pure β-TCP scaffold and 11% compared to coated β-TCP scaffold.