Cellular Barcoding Links B-1a B Cell Potential to a Fetal Hematopoietic Stem Cell State at the Single-Cell Level

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Cellular Barcoding Links B-1a B Cell Potential to a Fetal Hematopoietic Stem Cell State at the Single-Cell Level

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作者：Trine A. Kristiansen¹ ; Elin Jaensson Gyllenbä ; ck¹ ; Alya Zriwil¹ ; Tomas Bjö ; rklund² ; Jeremy A. Daniel³ ; Ewa Sitnicka¹ ; Shamit Soneji¹ ; David Bryder¹ ; Joan Yuan¹ ; ^{joan.yuan@med.lu.se" class="auth_mail" title="E-mail the corresponding author}
刊名：Immunity
出版年：2016
出版时间：16 August 2016
年：2016
卷：45
期：2
页码：346-357
全文大小：2005 K

文摘

•: Fetal liver definitive HSCs give rise to both B-1a and B-2 B cells
•: Initially B-1a potent HSCs become B-2 restricted upon secondary transplantation
•: Attenuation of B-1a potential is associated with gene expression changes at the single-cell level
•: Ectopic Lin28b reinitiates fetal regenerative potential in a subset of adult HSCs

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